Recombinant人BAPX1 protein (ab114496)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      RLFGERDAGALGGAEDSLLASPAGTRTAAGRTAESPEGWDSDSALSEENE SRRRCADAR
    • 分子量
      32 kDa including tags
    • 氨基酸
      53 to 111

技术指标

Our Abpromise guarantee covers the use of ab114496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Bagpipe homeobox 1
    • Bagpipe homeobox homolog 1
    • Bagpipe homeobox protein homolog 1
    • Bagpipe homeobox, Drosophila, homolog of, 1
    • BAPX 1
    • Homeobox protein NK-3 homolog B
    • Homeobox protein Nkx 3.2
    • Homeobox protein Nkx-3.2
    • MGC138171
    • NK3 homeobox 2
    • NKX3 2
    • NKX3-2
    • NKX3.2
    • NKX3.2, mouse, homolog of
    • NKX32_HUMAN
    • NKX3B
    • OTTHUMP00000115816
    • SMMD
    see all
  • 功能
    Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
  • 组织特异性
    Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
  • 疾病相关
    Defects in NKX3-2 are the cause of spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD) [MIM:613330]. It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet.
  • 序列相似性
    Belongs to the NK-3 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • ab114496 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

文献

ab114496 has not yet been referenced specifically in any publications.

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