Recombinant人Band 3 protein (ab114402)

概述

  • 产品名称Recombinant人Band 3 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP02730
    • 种属Human
    • 序列PIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHS LEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYK
    • 分子量37 kDa including tags
    • 氨基酸261 to 360

技术指标

Our Abpromise guarantee covers the use of ab114402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.03% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AE 1
    • AE1
    • Anion exchange protein 1
    • Anion exchanger 1
    • B3AT_HUMAN
    • Band 3 anion transport protein
    • BND3
    • CD233
    • DI
    • Diego blood group
    • EMPB3
    • EPB3
    • Erythrocyte membrane protein band 3
    • Erythroid anion exchange protein
    • FR
    • Froese blood group
    • RTA1A
    • SLC4A1
    • Solute carrier family 4 anion exchanger member 1
    • Solute carrier family 4 member 1
    • SW
    • Swann blood group
    • Waldner blood group
    • WD
    • WD1
    • WR
    • Wright blood group
    see all
  • 功能Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
  • 组织特异性Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871).
  • 疾病相关Ovalocytosis, Southeast Asian
    Spherocytosis 4
    Renal tubular acidosis, distal, autosomal dominant
    Renal tubular acidosis, distal, with hemolytic anemia
    Renal tubular acidosis, distal, with normal red cell morphology
    Cryohydrocytosis
  • 序列相似性Belongs to the anion exchanger (TC 2.A.31) family.
  • 翻译后修饰Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation.
    Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation.
    N-glycosylated.
  • 细胞定位Cell membrane. Basolateral cell membrane. Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.
  • Information by UniProt

Recombinant Human Band 3 protein 图像

  • 12.5% SDS-PAGE analysis of ab114402, stained with Coomassie Blue.

Recombinant Human Band 3 protein (ab114402)参考文献

ab114402 has not yet been referenced specifically in any publications.

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