Recombinant人Bag1 protein (ab85158)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸72 to 345

技术指标

Our Abpromise guarantee covers the use of ab85158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM MOPS, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • Bag 1
    • BAG family molecular chaperone regulator 1
    • BAG-1
    • BAG1
    • BAG1_HUMAN
    • BCL 2 associated athanogene
    • BCL 2 Associated Athanogene 1
    • BCL 2 binding athanogene 1
    • Bcl-2-associated athanogene 1
    • BCL2 associated athanogene
    • BCL2 associated athanogene 1
    • Glucocorticoid receptor-associated protein RAP46
    • HAP1
    • Haptoglobin
    • RAP 46
    • RAP46
    see all
  • 功能Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
  • 组织特异性Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
  • 序列相似性Contains 1 BAG domain.
    Contains 1 ubiquitin-like domain.
  • 翻译后修饰Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 细胞定位Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
  • Information by UniProt

Recombinant Human Bag1 protein 图像

  • SDS-PAGE showing ab85158 at approximately 66kDa.

Recombinant Human Bag1 protein (ab85158)参考文献

ab85158 has not yet been referenced specifically in any publications.

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