TNF homolog that activates apoptosis NKFB and JNK.
TNF- and APOL-related leukocyte expressed ligand 1
Tumor necrosis factor (ligand) superfamily member 13b
Tumor necrosis factor ligand superfamily member 13b
Tumor necrosis factor ligand superfamily member 20
Tumor necrosis factor like protein ZTNF4
Tumor necrosis factor superfamily member 13B
功能Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
组织特异性Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
序列相似性Belongs to the tumor necrosis factor family.
翻译后修饰The soluble form derives from the membrane form by proteolytic processing. N-glycosylated.