Recombinant人ATF6 beta protein (ab114637)

概述

  • 产品名称
    Recombinant人ATF6 beta protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRC PEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVK
    • 分子量
      35 kDa including tags
    • 氨基酸
      2 to 88

技术指标

Our Abpromise guarantee covers the use of ab114637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Activating transcription factor 6 beta
    • ATF 6 beta
    • ATF6-beta
    • ATF6B
    • ATF6B_HUMAN
    • ATF6beta
    • cAMP response element binding protein related protein
    • cAMP response element-binding protein-related protein
    • cAMP responsive element binding protein like 1
    • cAMP-dependent transcription factor ATF-6 beta
    • cAMP-responsive element-binding protein-like 1
    • CREB L1
    • Creb related protein
    • CREB RP
    • Creb-rp
    • CREBL 1
    • CREBL1
    • Crebrp
    • Cyclic AMP dependent transcription factor ATF 6 beta
    • Cyclic AMP dependent transcription factor ATF6 beta
    • FLJ10066
    • G13
    • G13 protein
    • OTTHUMP00000029432
    • OTTHUMP00000029433
    • Processed cyclic AMP-dependent transcription factor ATF-6 beta
    • Protein G13
    see all
  • 功能
    Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 结构域
    The basic domain functions as a nuclear localization signal.
    The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
  • 翻译后修饰
    N-glycosylated.
    During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
  • 细胞定位
    Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE image showing ab114637 Stained with Coomassie Blue.

文献

ab114637 has not yet been referenced specifically in any publications.

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