Recombinant人ARMET protein (ab123227)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
    • 分子量
      18 kDa
    • 氨基酸
      25 to 182

技术指标

Our Abpromise guarantee covers the use of ab123227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 µg/ml.
  • 应用

    Functional Studies

    SDS-PAGE

    HPLC

  • 内毒素水平
    < 0.100 Eu/µg
  • 纯度
    > 98 % SDS-PAGE.
    Purity is greater than 98% by SDS-PAGE gel and HPLC analyses.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Arginine rich mutated in early stage tumors
    • Arginine rich protein
    • Arginine-rich protein
    • ARMET
    • ARMET protein
    • ARP
    • Manf
    • MANF_HUMAN
    • Mesencephalic astrocyte derived neurotrophic factor
    • Mesencephalic astrocyte-derived neurotrophic factor
    • MGC142148
    • MGC142150
    • Protein ARMET
    see all
  • 功能
    Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
  • 序列相似性
    Belongs to the ARMET family.
  • 结构域
    The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
  • 翻译后修饰
    May contain sialic acid residues.
  • 细胞定位
    Secreted.
  • Information by UniProt

文献

ab123227 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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