Recombinant人Argininosuccinate Lyase protein (ab113605)

概述

  • 产品名称
    Recombinant人Argininosuccinate Lyase protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMASESGKLWGGRFVGAVDPIMEKFNASIAY DRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFK LNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCS TLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVAL TRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSM DATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTG SSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKE AVFEVSDTMSAVLQVATGVISTLQIHQENMGQALSPDMLATDLAYYLVRK GMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLFSGDVICVWDY GHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA
    • 分子量
      54 kDa including tags
    • 氨基酸
      1 to 464
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab113605 was purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.04% DTT, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Argininosuccinase
    • Argininosuccinate lyase
    • Arginosuccinase
    • ARLY_HUMAN
    • ASAL
    • ASL
    • EC 4.3.2.1
    see all
  • 通路
    Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
    Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.
  • 疾病相关
    Defects in ASL are the cause of arginosuccinicaciduria (ARGINSA) [MIM:207900]. Arginosuccinicaciduria is an autosomal recessive disorder of the urea cycle. The disease is characterized by mental and physical retardation, liver enlargement, skin lesions, dry and brittle hair showing trichorrhexis nodosa microscopically and fluorescing red, convulsions, and episodic unconsciousness.
  • 序列相似性
    Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
  • 翻译后修饰
    Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab113605 (3 µg) at approximately 53.8 kDa.

文献

ab113605 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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