Recombinant人APPBP1 protein (ab116199)

概述

  • 产品名称Recombinant人APPBP1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ13564
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGSMAQLGKLLKEQKYDRQLRLWGDHGQEA LESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQ RSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV ATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYS ETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALN TTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRG TIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISE KELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYL MLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQ TSATFQL
    • 分子量63 kDa including tags
    • 氨基酸1 to 534
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab116199 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • 59 kDa
    • A 116A10.1
    • Amyloid beta precursor protein binding protein 1
    • Amyloid beta precursor protein binding protein 1 59kD
    • Amyloid beta precursor protein binding protein 1 59kDa
    • Amyloid beta precursor protein binding protein 1, 59 kDa
    • Amyloid beta precursor protein-binding protein 1
    • Amyloid protein binding protein 1
    • Amyloid protein-binding protein 1
    • APP BP1
    • APP-BP1
    • APPBP 1
    • APPBP1
    • HPP 1
    • HPP1
    • NAE 1
    • NAE1
    • NEDD8 activating enzyme E1 regulatory subunit
    • NEDD8 activating enzyme E1 subunit
    • NEDD8 activating enzyme E1 subunit 1
    • NEDD8-activating enzyme E1 regulatory subunit
    • Proto oncogene protein 1
    • Proto-oncogene protein 1
    • Protooncogene protein 1
    • ula 1
    • ULA1_HUMAN
    see all
  • 功能Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
  • 组织特异性Ubiquitous in fetal tissues. Expressed throughout the adult brain.
  • 通路Protein modification; protein neddylation.
  • 序列相似性Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
  • 细胞定位Cell membrane. Colocalizes with APP in lipid rafts.
  • Information by UniProt

Recombinant Human APPBP1 protein 图像

  • 15% SDS-PAGE analysis of 3 µg ab116199.

Recombinant Human APPBP1 protein (ab116199)参考文献

ab116199 has not yet been referenced specifically in any publications.

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