Recombinant人APPBP1 protein (ab116199)

概述

  • 产品名称
    Recombinant人APPBP1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMGSMAQLGKLLKEQKYDRQLRLWGDHGQEA LESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQ RSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVV ATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYS ETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALN TTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRG TIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISE KELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYL MLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQ TSATFQL
    • 分子量
      63 kDa including tags
    • 氨基酸
      1 to 534
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.
    ab116199 was purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • 59 kDa
    • A 116A10.1
    • Amyloid beta precursor protein binding protein 1
    • Amyloid beta precursor protein binding protein 1 59kD
    • Amyloid beta precursor protein binding protein 1 59kDa
    • Amyloid beta precursor protein binding protein 1, 59 kDa
    • Amyloid beta precursor protein-binding protein 1
    • Amyloid protein binding protein 1
    • Amyloid protein-binding protein 1
    • APP BP1
    • APP-BP1
    • APPBP 1
    • APPBP1
    • HPP 1
    • HPP1
    • NAE 1
    • NAE1
    • NEDD8 activating enzyme E1 regulatory subunit
    • NEDD8 activating enzyme E1 subunit
    • NEDD8 activating enzyme E1 subunit 1
    • NEDD8-activating enzyme E1 regulatory subunit
    • Proto oncogene protein 1
    • Proto-oncogene protein 1
    • Protooncogene protein 1
    • ula 1
    • ULA1_HUMAN
    see all
  • 功能
    Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
  • 组织特异性
    Ubiquitous in fetal tissues. Expressed throughout the adult brain.
  • 通路
    Protein modification; protein neddylation.
  • 序列相似性
    Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
  • 细胞定位
    Cell membrane. Colocalizes with APP in lipid rafts.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3 µg ab116199.

文献

ab116199 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab116199.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册