Recombinant人AP2 alpha protein (ab114726)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP05549
    • 种属Human
    • 序列SGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPH AIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGV VNPNEVF
    • 分子量37 kDa including tags
    • 氨基酸99 to 205

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技术指标

Our Abpromise guarantee covers the use of ab114726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Activating enhancer binding protein 2 alpha
    • Activating enhancer-binding protein 2-alpha
    • Activator protein 2
    • AP 2 transcription factor
    • AP 2alpha
    • AP-2
    • AP-2 transcription factor
    • AP2
    • AP2 Transcription Factor
    • AP2-alpha
    • AP2A_HUMAN
    • AP2TF
    • BOFS
    • FLJ51761
    • TFAP 2
    • TFAP 2A
    • TFAP2
    • TFAP2A
    • Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha)
    • Transcription factor AP-2-alpha
    • Transcription factor AP2 alpha
    see all
  • 功能Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.
  • 疾病相关Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major features include cutaneous anomalies, ocular anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair) anomalies.
  • 序列相似性Belongs to the AP-2 family.
  • 结构域The WW-binding motif mediates interaction with WWOX.
  • 翻译后修饰Sumoylated on Lys-10; which inhibits transcriptional activity.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human AP2 alpha protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human AP2 alpha protein (ab114726)参考文献

ab114726 has not yet been referenced specifically in any publications.

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