Recombinant人AP1S2 protein (ab108122)

概述

  • 产品名称Recombinant人AP1S2 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP56377
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITL EIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNV LKAIEQADLLQEEAETPRSVLEEIGLT
    • 分子量21 kDa including tags
    • 氨基酸1 to 157
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab108122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 85 % SDS-PAGE.
    ab108122 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 40% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • Adapter related protein complex 1 sigma 1B subunit
    • Adapter-related protein complex 1 sigma-1B subunit
    • Adaptor protein complex AP 1 sigma 1B subunit
    • Adaptor protein complex AP-1 sigma-1B subunit
    • Adaptor related protein complex 1 sigma 2 subunit
    • AP 1 complex subunit sigma 2
    • AP-1 complex subunit sigma-2
    • ap1s2
    • AP1S2_HUMAN
    • Clathrin adaptor complex AP1 sigma 1B subunit
    • Clathrin assembly protein complex 1 sigma 1B small chain
    • Clathrin assembly protein complex 1 sigma-1B small chain
    • Clathrin associated assembly adaptor protein small 1 like
    • DC22
    • Golgi adaptor HA1 AP1 adaptin sigma 1B subunit
    • Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
    • mental retardation X linked 59
    • MGC:1902
    • MRX59
    • Sigma 1B subunit of AP 1 clathrin
    • Sigma 1B subunit of AP-1 clathrin
    • Sigma adaptin 1B
    • Sigma-adaptin 1B
    • SIGMA1B
    • Sigma1B adaptin
    • Sigma1B-adaptin
    see all
  • 功能Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in AP1S2 are the cause of mental retardation X-linked type 59 (MRX59) [MIM:300630]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. MRX59 consists of a mild-to-profound mental retardation. Other features includes hypotonia early in life and delay in walking.
  • 序列相似性Belongs to the adaptor complexes small subunit family.
  • 细胞定位Golgi apparatus. Cytoplasmic vesicle membrane. Membrane > clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • Information by UniProt

Recombinant Human AP1S2 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab108122.

Recombinant Human AP1S2 protein (ab108122)参考文献

ab108122 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab108122.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"