Recombinant人AMFR protein (ab114887)

概述

  • 产品名称
    Recombinant人AMFR protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQV PFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLD
    • 分子量
      37 kDa including tags
    • 氨基酸
      451 to 550

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AMF receptor
    • AMF receptor isoform 1
    • AMF receptor isoform 2
    • AMFR
    • AMFR2_HUMAN
    • Autocrine motility factor receptor
    • Autocrine motility factor receptor precursor, isoform 1
    • Autocrine motility factor receptor precursor, isoform 2
    • E3 ubiquitin-protein ligase AMFR
    • gp78
    • isoform 2
    • RING finger protein 45
    • RNF 45
    • RNF45
    see all
  • 功能
    E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 CUE domain.
    Contains 1 RING-type zinc finger.
  • 细胞定位
    Endoplasmic reticulum membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab114887 at approximately 36.63kDa.
    Stained with Coomassie Blue.

文献

ab114887 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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