Recombinant人alpha Actinin 4 protein (ab126006)

概述

  • 产品名称
    Recombinant人alpha Actinin 4 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      29 kDa
    • 氨基酸
      397 to 648

技术指标

Our Abpromise guarantee covers the use of ab126006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶
    Reconstitute with water to desired concentration.

常规信息

  • 别名
    • actinin 4
    • Actinin alpha 4
    • actinin4
    • ACTN 4
    • ACTN4
    • ACTN4_HUMAN
    • Alpha-actinin-4
    • DKFZp686K23158
    • F actin cross linking protein
    • F-actin cross-linking protein
    • Focal segmental glomerulosclerosis 1
    • FSGS
    • FSGS 1
    • FSGS1
    • Non muscle alpha actinin 4
    • Non-muscle alpha-actinin 4
    see all
  • 功能
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
  • 组织特异性
    Widely expressed.
  • 疾病相关
    Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • 序列相似性
    Belongs to the alpha-actinin family.
    Contains 1 actin-binding domain.
    Contains 2 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
    Contains 4 spectrin repeats.
  • 细胞定位
    Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.
  • Information by UniProt

Recombinant Human alpha Actinin 4 protein (ab126006)参考文献

ab126006 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab126006.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册