Recombinant人alpha Actinin 4 protein (ab126006)

概述

  • 产品名称Recombinant人alpha Actinin 4 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO43707
    • 种属Human
    • 分子量29 kDa
    • 氨基酸397 to 648

技术指标

Our Abpromise guarantee covers the use of ab126006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • actinin 4
    • Actinin alpha 4
    • actinin4
    • ACTN 4
    • ACTN4
    • ACTN4_HUMAN
    • Alpha-actinin-4
    • DKFZp686K23158
    • F actin cross linking protein
    • F-actin cross-linking protein
    • Focal segmental glomerulosclerosis 1
    • FSGS
    • FSGS 1
    • FSGS1
    • Non muscle alpha actinin 4
    • Non-muscle alpha-actinin 4
    see all
  • 功能F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • 序列相似性Belongs to the alpha-actinin family.
    Contains 1 actin-binding domain.
    Contains 2 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
    Contains 4 spectrin repeats.
  • 细胞定位Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.
  • Information by UniProt

Recombinant Human alpha Actinin 4 protein (ab126006)参考文献

ab126006 has not yet been referenced specifically in any publications.

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