Recombinant人ALDH5A1 protein (ab99429)

概述

  • 产品名称
    Recombinant人ALDH5A1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMAGRLAGLSAALLRTDSFVGGRWLPAAATF PVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRK WYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVV VKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVA GAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLE LKYVCYGGL
    • 分子量
      55 kDa including tags
    • 氨基酸
      48 to 535
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab99429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab99429 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Aldedehyde dehydrogenase 5 family
    • Aldehyde dehydrogenase 5 family member A1
    • Aldehyde dehydrogenase 5A1
    • Aldehyde dehydrogenase family 5 member A1
    • ALDH5A 1
    • Aldh5a1
    • mitochondrial
    • Mitochondrial succinate semialdehyde dehydrogenase
    • NAD(+) dependent succinic semialdehyde dehydrogenase
    • NAD(+)-dependent succinic semialdehyde dehydrogenase
    • SSADH
    • SSDH
    • SSDH_HUMAN
    • Succinate semialdehyde dehydrogenase
    • Succinate-semialdehyde dehydrogenase
    see all
  • 功能
    Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • 组织特异性
    Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • 通路
    Amino-acid degradation; 4-aminobutanoate degradation.
  • 疾病相关
    Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • 序列相似性
    Belongs to the aldehyde dehydrogenase family.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt

Recombinant Human ALDH5A1 protein 图像

  • 15% SDS-PAGE showing ab99429 at approximately 54.6kDa (3µg).

Recombinant Human ALDH5A1 protein (ab99429)参考文献

ab99429 has not yet been referenced specifically in any publications.

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