Recombinant人AKR1A1 protein (ab117169)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIY GNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLA DLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEAL VAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHC QARGLEVTAYSPLGSSDRAWRDPDEPVLLEPVVLALAEKYGRSPAQILLR WQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP MLTVDGKRVPRDAGHPLYPFNDPY
    • 分子量
      37 kDa
    • 氨基酸
      1 to 325

相关产品

技术指标

Our Abpromise guarantee covers the use of ab117169 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.
    ab117169 is purified by proprietary chromatographic techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.15% Tris, 0.29% Sodium chloride, 10% Glycerol

常规信息

  • 别名
    • AK1A1_HUMAN
    • Akr1a1
    • Alcohol dehydrogenase
    • Alcohol dehydrogenase [NADP+]
    • Aldehyde reductase
    • Aldo keto reductase family 1 member A1 (aldehyde reductase)
    • Aldo-keto reductase family 1 member A1
    • ALDR1
    • ALR
    • ARM
    • DD3
    • MGC12529
    • MGC1380
    see all
  • 功能
    Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
  • 组织特异性
    Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 序列相似性
    Belongs to the aldo/keto reductase family.
  • Information by UniProt

文献

ab117169 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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