重组人AGRP蛋白(His tag) (ab202619)
Key features and details
- Expression system: Escherichia coli
- Purity: > 85% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
描述
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产品名称
重组人AGRP蛋白(His tag)
参阅全部 AGRP 蛋白酶 -
纯度
> 85 % SDS-PAGE.
ab202619 was purified by using conventional chromatography techniques. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MGSSHHHHHHSSGLVPRGSHMGSHMAQMGLAPMEGIRRPDQALLPELPGL GLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCL GQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT -
预测分子量
15 kDa including tags -
氨基酸
21 to 132 -
标签
His tag N-Terminus -
额外的序列信息
NP_001129. Mature full length protein without signal peptide.
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab202619 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Mass Spectrometry
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质谱法
MALDI-TOF -
形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.50
Constituents: 0.32% Tris HCl, 20% Glycerol (glycerin, glycerine), 0.02% DTT
常规信息
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别名
- Agouti related neuropeptide
- Agouti Related Protein Homolog
- Agouti-related protein
see all -
功能
Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R. -
组织特异性
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. -
疾病相关
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. -
序列相似性
Contains 1 agouti domain. -
结构域
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. -
细胞定位
Secreted. Golgi apparatus lumen. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab202619 尚未被引用在任何文献中。