Recombinant人ADRB2 GsaS fusion protein (ab90624)

概述

  • 产品名称Recombinant人ADRB2 GsaS fusion protein
  • 蛋白长度Full length protein
  • 描述
    Recombinant人ADRB2 GsαS fusion protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab90624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Activity: 1.3-7 pmol/mg
  • 形式Liquid
  • 补充说明


    ab90624 ensures a defined 1:1 stoichiometry of the receptor and the GsaS subunit as well as high coupling efficiency. ab90624 does not exhibit the hallmarks of constitutive activity, e.g. high efficacies of partial agonists and inverse agonists and AC activation by the agonist-free beta2AR.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surface
    • B2AR
    • BAR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • Catecholamine receptor
    see all
  • 相关性Beta adrenergic receptors mediate the catecholamine induced activation of adenylate cyclase through the action of G proteins. The beta 2 adrenergic receptor binds epinephrine with an approximately 30 fold greater affinity than it does norepinephrine. The beta 2 adrenergic receptor is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase (AC) activation. The beta 2 adrenergic receptors are found in numerous tissues and cell types including vascular and bronchial smooth muscle cells, leukocytes and liver. The beta 2 adrenergic receptors mediate smooth muscle relaxation, inhibition of leukocyte function and activation of glycogenolysis. GsaS is the short splice variant of the alpha subunit of the heterotrimeric G protein Gs. Gs activates the effector AC.
  • 细胞定位Cell membrane; Multi pass membrane protein.

Recombinant human ADRB2 GsaS fusion protein (ab90624)参考文献

ab90624 has not yet been referenced specifically in any publications.

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