Recombinant人ADRB2 + GsaL fusion protein (ab90837)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 额外的序列信息DDDDK tagged N terminus of ADRB2. ADRB2 C terminus linked to the N terminus of the GsaL with His tag. This fusion protein contains a thrombin cleavage site (TS) between the His tag and GsaL subunit.

技术指标

Our Abpromise guarantee covers the use of ab90837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Activity: 4.2 pmol/mg
  • 应用

    Functional Studies

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Adenylate cyclase stimulating G alpha protein
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptor surface
    • AHO
    • B2AR
    • BAR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • Beta 2 adrenoreceptor
    • BETA2AR
    • C20orf45
    • Catecholamine receptor
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    see all
  • 相关性ADRB2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. ADRB2 binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. GsaL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. It differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.
  • 细胞定位ADRB2: Cell membrane; Multi-pass membrane protein

Recombinant human ADRB2 + GsaL fusion protein (ab90837)参考文献

ab90837 has not yet been referenced specifically in any publications.

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