Recombinant人ADRB2 (CAM) + GsaL fusion protein (ab90773)

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概述

  • 产品名称
    Recombinant人ADRB2 (CAM) + GsaL fusion protein
  • 蛋白长度
    Full length protein
  • 描述
    Recombinant人ADRB2 (CAM) + GsαL fusion protein

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 分子量
      104 kDa
    • 额外的序列信息
      Tagged at the N terminus of the ADRB2 with a DDDDK tag. The C terminus of the ADRB2 is linked to the N terminus of the Gs alpha L with a His tag.

技术指标

Our Abpromise guarantee covers the use of ab90773 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Activity: 2.4 - 4.9 pmol/mg
  • 应用

    Functional Studies

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Adenylate cyclase stimulating G alpha protein
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptorsurface
    • AHO
    • B2AR
    • BAR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • BETA2AR
    • C20orf45
    • Catecholamine receptor
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide regulatory protein
    • MGC33735
    • NESP
    • PHP1A
    • PHP1B
    • POH
    see all
  • 相关性
    ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. ADBR2 receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADBR2CAM is a constitutively active mutant of the ADBR2. It differs from the wild-type receptor by four discrete amino acid substitutions in the third intracellular loop of the receptor L266 to S266, K267 to R267, H269 to K269, and L272 to A272). GsaL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. Gs activates the effector adenylate cyclase. GsaL differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.
  • 细胞定位
    ADRB2: Cell membrane; Multi-pass membrane protein.

Recombinant human ADRB2 (CAM) + GsaL fusion protein (ab90773)参考文献

ab90773 has not yet been referenced specifically in any publications.

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