重组人ADRB2 (CAM) + GsaL fusion蛋白(ab90773)

ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. ADBR2 receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADBR2_CAM is a constitutively active mutant of the ADBR2. It differs from the wild-type receptor by four discrete amino acid substitutions in the third intracellular loop of the receptor L266 to S266, K267 to R267, H269 to K269, and L272 to A272). G_saL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. Gs activates the effector adenylate cyclase. G_saL differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.

ADRB2: Cell membrane; Multi-pass membrane protein.