Recombinant人ADRB1 Gly389 + GsaS fusion protein (ab90781)

概述

  • 产品名称Recombinant人ADRB1 Gly389 + GsaS fusion protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP08588
    • 种属Human
    • 分子量104 kDa
    • 额外的序列信息Tagged at the N terminus of the ADRB1 with a DDDDK tag. The C terminus of the ADRB1 is linked to the N terminus of the Gs alpha S with a His tag.

技术指标

Our Abpromise guarantee covers the use of ab90781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Receptor expression level: 2 - 10 pmol/mg
  • 应用

    Functional Studies

  • 形式Liquid
  • 补充说明Receptor expression level: 2 - 10 pmol/mg
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Adenylate cyclase stimulating G alpha protein
    • ADRB1
    • ADRB1R
    • Adrenergic beta1 receptor
    • AHO
    • B1AR
    • Beta 1 adrenergic receptor
    • Beta 1 adrenoreceptor
    • BETA1AR
    • C20orf45
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    • RHR
    see all
  • 相关性ADRB1 belongs to a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in ADRB1 have been shown to affect the resting heart rate and can be involved in heart failure. ADRB1 Gly389 is a common polymorphic variant of ADRB1. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. G-protein Alpha S Short is the short splice variant of the alpha subunit of the heterotrimeric G protein Gs.
  • 细胞定位ADRB1: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression

Recombinant human ADRB1 Gly389 + GsaS fusion protein (ab90781)参考文献

ab90781 has not yet been referenced specifically in any publications.

Product Wall

The current lot of ab90781 is 1 mg/mL. Please contact us directly for the concentrations of future lots.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"