This product is an active protein and may elicit a biological response in vivo, handle with caution.
Adenylate cyclase inhibiting G alpha protein
Adrenergic beta 2 receptor surface
beta 2 adrenoceptor
Beta 2 adrenoreceptor
Beta subunit signal transducing proteins GS/GI
G gamma I
G protein beta 1 subunit
GTP binding regulatory protein Gi alpha 2 chain
Guanine nucleotide binding protein beta 1 subunit
Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2
Guanine nucleotide binding protein gamma 2
Transducin beta chain 1
相关性ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chain 2 is a subunit of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
GNB1 is a beta subunit. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
细胞定位ADBR2 and ?1: Cell Membrane
Gia2: Plasma Membrane
Recombinant human ADBR2 + Gia2 fusion co-expressed with ß1 and ?1 protein (ab90755)参考文献
has not yet been referenced specifically in any publications.