Recombinant人ADAM17 protein (ab114186)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      RADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRN TSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV
    • 分子量
      37 kDa including tags
    • 氨基酸
      215 to 314

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技术指标

Our Abpromise guarantee covers the use of ab114186 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • A disintegrin and metalloproteinase domain 17
    • A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
    • ADA17_HUMAN
    • ADAM 17
    • ADAM metallopeptidase domain 17
    • ADAM17
    • ADAM17 protein
    • CD 156b
    • CD156b
    • CD156b antigen
    • CSVP
    • Disintegrin and metalloproteinase domain-containing protein 17
    • MGC71942
    • NISBD
    • NISBD1
    • Snake venom like protease
    • Snake venom-like protease
    • TACE
    • TNF alpha convertase
    • TNF alpha converting enzyme
    • TNF-alpha convertase
    • TNF-alpha-converting enzyme
    • Tumor Necrosis Factor Alpha Converting Enzyme
    see all
  • 功能
    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
  • 组织特异性
    Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
  • 序列相似性
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • 结构域
    Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰
    The precursor is cleaved by a furin endopeptidase.
    Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • ab114186 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

文献

ab114186 has not yet been referenced specifically in any publications.

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