Recombinant人ADAM12 protein (ab53659)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸208 to 738

技术指标

Our Abpromise guarantee covers the use of ab53659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • A disintegrin and metalloproteinase domain 12
    • ADA12_HUMAN
    • ADAM 12
    • ADAM metallopeptidase domain 12
    • ADAM12
    • Disintegrin and metalloproteinase domain-containing protein 12
    • MCMP
    • MCMPMltna
    • Meltrin alpha
    • Meltrin-alpha
    • MLTN
    • MLTNA
    • OTTHUMP00000046766
    see all
  • 功能Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
  • 组织特异性Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • 结构域The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt

Recombinant Human ADAM12 protein (ab53659)参考文献

ab53659 has not yet been referenced specifically in any publications.

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