Recombinant人ADAM10 protein (ab83118)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸214 to 672

技术指标

Our Abpromise guarantee covers the use of ab83118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 1x Laemmli Buffer (2.5% Glycerol, 1% SDS, 0.1% Bromophenol blue, 50mM DTT, 25mM Tris HCl, pH 6.8)

常规信息

  • 别名
    • A disintegrin and metalloprotease domain 10
    • A disintegrin and metalloproteinase domain 10
    • AD 10
    • AD10
    • ADA10_HUMAN
    • ADAM 10
    • ADAM metallopeptidase domain 10
    • ADAM10
    • CD 156c
    • CD156c
    • CD156c antigen
    • CDw156
    • disintegrin and metalloproteinase domain containing protein 10
    • Disintegrin and metalloproteinase domain-containing protein 10
    • HsT 18717
    • HsT18717
    • Kuz
    • Kuzbanian
    • Kuzbanian protein homolog
    • MADM
    • Mammalian disintegrin metalloprotease
    • Mammalian disintegrin-metalloprotease
    see all
  • 功能Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-
    -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
  • 组织特异性Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
  • 结构域The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Cell membrane. Endomembrane system. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
  • Information by UniProt

Recombinant Human ADAM10 protein (ab83118)参考文献

ab83118 has not yet been referenced specifically in any publications.

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