Recombinant人Acetyl Coenzyme A carboxylase alpha protein (ab79625)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      39 to 2346

技术指标

Our Abpromise guarantee covers the use of ab79625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.05% Tween 20, 50mM Tris HCl, 3mM DTT, 150mM Sodium chloride, 0.1mM EDTA, 0.1mM EGTA, pH 7.5

常规信息

  • 别名
    • ACAC
    • ACACA
    • ACACA_HUMAN
    • ACC alpha
    • ACC-alpha
    • ACC1
    • ACCA
    • Acetyl Coenzyme A
    • Biotin carboxylase
    see all
  • 功能
    Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
  • 组织特异性
    Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
  • 通路
    Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
  • 疾病相关
    Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
  • 序列相似性
    Contains 1 ATP-grasp domain.
    Contains 1 biotin carboxylation domain.
    Contains 1 biotinyl-binding domain.
    Contains 1 carboxyltransferase domain.
  • 翻译后修饰
    Phosphorylation on Ser-1263 is required for interaction with BRCA1.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

Recombinant Human Acetyl Coenzyme A carboxylase alpha protein (ab79625)参考文献

ab79625 has not yet been referenced specifically in any publications.

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