Recombinant人ABCB5 protein (ab125989)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDA KELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDE ATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKI KEQG
    • 氨基酸
      587 to 790

技术指标

Our Abpromise guarantee covers the use of ab125989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 28.8% Guanidine HCl

  • 复溶
    Reconstitute with water to desired concentration.

常规信息

  • 别名
    • ABCB 5
    • ABCB5
    • ABCB5 P-gp
    • ABCB5_HUMAN
    • ABCB5alpha
    • ABCB5beta
    • ATP binding cassette protein
    • ATP binding cassette sub family B (MDR/TAP) member 5
    • ATP binding cassette sub family B member 5
    • ATP-binding cassette sub-family B member 5
    • EST422562
    • P glycoprotein ABCB5
    • P-glycoprotein ABCB5
    see all
  • 功能
    Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
  • 组织特异性
    Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
  • 序列相似性
    Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 2 ABC transporter domains.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

Recombinant Human ABCB5 protein (ab125989)参考文献

ab125989 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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