Recombinant人ABCA1 protein (ab125995)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      NCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNR FGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSL SSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLS LHKNQTVVDVA
    • 氨基酸
      2085 to 2245

技术指标

Our Abpromise guarantee covers the use of ab125995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 0.2% Guanidine HCl

  • 复溶
    Reconstitute with water to desired concentration.

常规信息

  • 别名
    • ABC 1
    • ABC Transporter 1
    • ABC-1
    • ABC1
    • ABCA 1
    • ABCA1
    • ABCA1_HUMAN
    • ATP binding Cassette 1
    • ATP binding cassette sub family A ABC1 member 1
    • ATP binding cassette sub family A member 1
    • ATP binding Cassette Transporter 1
    • ATP-binding cassette 1
    • ATP-binding cassette sub-family A member 1
    • ATP-binding cassette transporter 1
    • CERP
    • Cholesterol efflux regulatory protein
    • FLJ14958
    • HDLDT1
    • Membrane bound
    • MGC164864
    • MGC165011
    • TD
    • TGD
    see all
  • 功能
    cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
  • 组织特异性
    Widely expressed, but most abundant in macrophages.
  • 疾病相关
    Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
    Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
  • 序列相似性
    Belongs to the ABC transporter superfamily. ABCA family.
    Contains 2 ABC transporter domains.
  • 结构域
    Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
  • 翻译后修饰
    Phosphorylation on Ser-2054 regulates phospholipid efflux.
    Palmitoylation by DHHC8 is essential for membrane localization.
  • 细胞定位
    Membrane.
  • Information by UniProt

文献

ab125995 has not yet been referenced specifically in any publications.

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