Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.
Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.
Belongs to the P-Pant transferase superfamily. AcpS family.
Phosphorylated upon DNA damage, probably by ATM or ATR.