Recombinant人67kDa Laminin Receptor protein (ab112316)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      EVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEV ADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
    • 分子量
      37 kDa including tags
    • 氨基酸
      196 to 295
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    Peptide Array

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced.

常规信息

  • 别名
    • 34/67 kDa laminin receptor
    • 37 kDa laminin receptor precursor
    • 37/67 kDa laminin receptor
    • 37LRP
    • 40S ribosomal protein SA
    • 67 kDa laminin receptor
    • 67LR
    • Colon carcinoma laminin binding protein
    • Colon carcinoma laminin-binding protein
    • LAMBR
    • Laminin receptor 1
    • Laminin-binding protein precursor p40
    • LamR
    • LAMR 1
    • LAMR1
    • LBP
    • LBP/p40
    • LRP
    • LRP/LR
    • Multidrug resistance associated protein MGr1 Ag
    • Multidrug resistance associated protein MGr1Ag
    • Multidrug resistance-associated protein MGr1-Ag
    • NEM/1CHD4
    • p40
    • Ribosomal Protein SA
    • rpsA
    • RSSA_HUMAN
    • SA
    see all
  • 功能
    Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
  • 序列相似性
    Belongs to the ribosomal protein S2P family.
  • 翻译后修饰
    Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
    Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
  • 细胞定位
    Cell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
  • Information by UniProt

图片

  • ab112316 on a 12.5% SDS-PAGE Stained with Coomassie Blue

文献

This product has been referenced in:
  • McClintock SD  et al. Monoclonal antibodies specific for oncofetal antigen--immature laminin receptor protein: Effects on tumor growth and spread in two murine models. Cancer Biol Ther 16:724-32 (2015). Read more (PubMed: 25799942) »

See 1 Publication for this product

客户评价及客户问答

Regarding your enquiry about Human 67kDa Laminin Receptor protein fragment, ab112316, I am sorry but we have not determined the molar extinction coefficient of the product.
As it contains reduced Glutathione in the storage buffer, we quantify its c...

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Thank you for your email and interest in Abcam products. ab112316 is only a fragment of the Laminin Receptor protein (UniProt P08865). It consists of 100 amino acids (position 196-295) and an additional tag. Therefore, the predicted molecular weigh...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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