Recombinant人14-3-3 sigma protein (ab85271)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab85271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 95 % SDS-PAGE.
    Purity was determined to be >95% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • 14 3 3 protein sigma
    • 14-3-3 protein sigma
    • 1433S_HUMAN
    • Epithelial cell marker protein 1
    • Er
    • HME 1
    • HME1
    • MGC143283
    • Mkrn3
    • Mme1
    • OTTHUMP00000004242
    • RP23 137L22.11
    • SFN
    • SFN protein
    • Stratifin
    • YWHAS
    see all
  • 功能Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
    p53-regulated inhibitor of G2/M progression.
  • 组织特异性Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
  • 序列相似性Belongs to the 14-3-3 family.
  • 翻译后修饰Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
  • 细胞定位Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
  • Information by UniProt

Recombinant Human 14-3-3 sigma protein 图像

  • SDS-PAGE showing ab85271 at approximately 29kDa.

Recombinant Human 14-3-3 sigma protein (ab85271)参考文献

ab85271 has not yet been referenced specifically in any publications.

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