Recombinant HIV1 Nef protein (ab58914)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 氨基酸3 to 190

技术指标

Our Abpromise guarantee covers the use of ab58914 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This product reacts strongly with human HIV positive serum.
  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    Purity is >95% as determined by SDS-PAGE and spectrophotometry.
  • 形式Liquid
  • 补充说明This product reacts strongly with human HIV positive serum.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10mM Sodium Carbonate, 14mM Beta mercaptoethanol, 10mM EDTA, pH 8

常规信息

  • 别名
    • C terminal core protein
    • F protein
    • Nef
    • Negative factor
    • p27
    see all
  • 相关性Nef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.

Recombinant HIV1 Nef protein (ab58914)参考文献

ab58914 has not yet been referenced specifically in any publications.

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