The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Store at -80°C.
Constituent: 0.1% Glycerol
ab119447 should be reconstituted in apirogenic sterile water or PBS buffer. Reconstituted protein should be used immediately.
Transactivating regulatory protein
The transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced.
Tat is an important potential target for antiretrovirals and vaccine development.
Recombinant HIV tat (mutated C31 A + C34 A) protein (ab119447)参考文献
has not yet been referenced specifically in any publications.