Recombinant丙型肝炎病毒NS4 protein (ab49028)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 氨基酸1658 to 1863

技术指标

Our Abpromise guarantee covers the use of ab49028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Reacts strongly with human HCV positive serum.
  • 应用

    ELISA

    Western blot

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明Reacts strongly with human HCV positive serum.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8

常规信息

  • 别名
    • HCV
    • HCV NS4
    • Hepatitis C Virus nonstructural antigen 4
    • Non structural protein 4A
    • Non structural protein 4B
    • NS4A
    • NS4B
    • p27
    • p8
    see all
  • 相关性NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
  • 细胞定位Endoplasmic reticulum; multi-pass membrane protein.

Recombinant Hepatitis C Virus NS4 protein 图像

Recombinant Hepatitis C Virus NS4 protein (ab49028)参考文献

ab49028 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. The antibody ab2591 will detect ab49028 and the antibody ab2583 will detect ab49015 in ELISA. A standard protocol for direct ELISA can be found under the following link: http://www.abcam.com/index.html?pageconfig=res...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"