概述
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产品名称Recombinant丙型肝炎病毒丙型肝炎病毒NS4 protein
参阅全部 Hepatitis C Virus NS4 蛋白酶 -
蛋白长度Protein fragment
描述
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性质Recombinant
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来源Escherichia coli
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氨基酸序列
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种属Hepatitis C virus
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序列MNRLI AFASRGNHVS PTHYVPESDA AARVTQI
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氨基酸1916 to 1947
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技术指标
Our Abpromise guarantee covers the use of ab49026 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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生物活性Strongly reacts with human HCV positive serum.
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应用
Western blot
ELISA
Flow Cytometry
SDS-PAGE
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纯度> 95 % SDS-PAGE.
Purity of proteins is evaluated by SDS-PAGE -
形式Liquid
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补充说明Strongly reacts with human HCV positive serum.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 50% Glycerol, 0.2% Triton-X, 1.5M Urea, 25mM Tris HCl, pH 8
常规信息
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别名
- HCV
- HCV NS4
- Hepatitis C Virus nonstructural antigen 4
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相关性NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
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细胞定位Endoplasmic reticulum; multi-pass membrane protein.
Recombinant Hepatitis C Virus Hepatitis C Virus NS4 protein (ab49026)参考文献
ab49026 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"