Recombinant丙型肝炎病毒Core 1b protein (Beta-Galactosidase) (ab67745)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ68873
    • 序列mstnpkpqrk tkrntnrrpq dvkfpgvgqi vggvyllprr gprlgvratr ktsersqprg rrqpipkarr pegrtwaqpg ypwplygneg cgwagwllsp rgsrpswgpt dprrrsrnlg kvidtltcgf adlmgyiplv gaplggaara lahgvrvled gvnyatgnlp gcsfsiflla llscltvpa
    • 分子量22 kDa
    • 氨基酸2 to 192
    • 额外的序列信息The E.coli derived recombinant protein contains the HCV core nucleocapsid genotype 1b, immunodominant regions, amino acids 2-192, 22kDa.

技术指标

Our Abpromise guarantee covers the use of ab67745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This protein is immunoreactive with sera of HCV-infected individuals.
  • 应用

    Western blot

    ELISA

  • 纯度> 95 % SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques.
  • 形式Liquid
  • 补充说明

    test .

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Capsid protein C
    • Core protein p19
    • Core protein p21
    • Hepatitis C virus core protein
  • 相关性HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
  • 细胞定位Secreted; Host endoplasmic reticulum membrane; Single-pass membrane protein; Host nucleus; Host cytoplasm.

Recombinant Hepatitis C Virus Core 1b protein (Beta-Galactosidase) (ab67745)参考文献

ab67745 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. Unfortunately, we have not tested the LPS (lipopolysaccharide) levels for this product to date, so it might contain a bit since we do use pyrogen free water for the purification. Regarding suitable products, I am afr...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"