Recombinant HA1 (H9N2) protein (ab67740)

概述

  • 产品名称Recombinant HA1 (H9N2) protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected insect cells

技术指标

Our Abpromise guarantee covers the use of ab67740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

  • 纯度> 90 % SDS-PAGE.
    sterile filtered.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.01% Tween 20, 150mM Sodium chloride, 10mM Sodium phosphate, pH 7.0

常规信息

  • 别名
    • Hemagglutinin
  • 相关性Hemagglutinin (HA) is a class I viral fusion protein from the Influenza virus. It is a major glycoprotein, comprising over 80% of the envelope proteins present in the virus particle. HA binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell, and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. The HA protein is a homotrimer of disulfide-linked HA1-HA2. It also plays a major role in the determination of host range restriction and virulence. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains. Influenza A subtypes are classified based on the combination of the virus coat glycoproteins, hemagglutinin (HA) and neuraminidase (NA). H9N2 influenza A viruses circulate worldwide. Since the mid-1990s, H9 viruses have become adapted to land-based birds and have crossed sporadically to pigs and humans, causing mild respiratory disease. Importantly, some of the currently circulating H9N2 viruses bind to sialic acid receptors linked to galactose in the {alpha}-2,6 conformation, which is the preferential binding pattern of human influenza viruses. Thus, these H9N2 viruses possess one of the key elements needed to establish stable lineages in humans.
  • 细胞定位viral envelope; apical plasma membrane. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts (By similarity).

Recombinant HA1 (H9N2) protein (ab67740)参考文献

ab67740 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry. The protein is made in SF+ cells - a proprietary cell line. Also, the cell media is serum free. I hope this information helps. Please contact us with any other questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"