Recombinant豚鼠HRH1 protein (ab90420)

概述

描述

  • 性质Recombinant
  • 来源Insect cells
  • 氨基酸序列
    • 种属Guinea pig

技术指标

Our Abpromise guarantee covers the use of ab90420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

  • 形式Liquid
  • 补充说明


    Small HRH1 agonists exhibit similar effects at Human HRH1 and guinea pig HRH1, whereas bulkier 2-phenylhistamines and histaprodifens are up to ~10-fold more potent at guinea pig HRH1 than at Human HRH1. Several first-generation HRH1 antagonists are ~2-fold, and arpromidine-type HRH1 antagonists up to ~10-fold more potent at guinea pig HRH1 than at Human HRH1.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

常规信息

  • 别名
    • BPHS, mouse, homolog of
    • H1 R
    • H1R
    • HH1R
    • HisH1
    • Histamine H(1) receptor
    • Histamine H1 receptor
    • Histamine receptor H1
    • Histamine receptor subclass H1
    • Hrh1
    • HRH1_HUMAN
    see all
  • 功能In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.
  • 细胞定位Cell membrane.
  • Information by UniProt

Recombinant Guinea pig HRH1 protein (ab90420)参考文献

ab90420 has not yet been referenced specifically in any publications.

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