Recombinant鸡IL16 protein (ab87694)

概述

描述

  • 性质
    Recombinant
  • 来源
    Yeast
  • 氨基酸序列
    • 种属
      Chicken
    • 序列
      SSTSSVASDA SQESTTEETI CTITLDKTAA GLGFSLEGGK GSIHGDKPII INRIFKGTSL EQSSPVQPGD ELLQVHTTAL QGLTRFEAWN IIKALPDGPI TAIIKRKNPS SVTKKASETL
    • 氨基酸
      487 to 607

技术指标

Our Abpromise guarantee covers the use of ab87694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The biological activity of ab87694 was determined in a chemotaxis assay using a Boyden chamber with chicken PBMC following initial culture with IL16. Bioactivity is typically detected starting at 78 ng/mL.
  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Trehalose, 1X PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

常规信息

  • 别名
    • HGNC:5980
    • HsT19289
    • IL-16
    • IL16
    • IL16_HUMAN
    • Interleukin 16 precursor
    • Interleukin-16
    • LCF
    • Lymphocyte chemoattractant factor
    • Neuronal interleukin 16
    • NIL16
    • prIL 16
    • PrIL16
    • Prointerleukin 16
    see all
  • 功能
    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 组织特异性
    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • 序列相似性
    Contains 4 PDZ (DHR) domains.
  • 翻译后修饰
    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • 细胞定位
    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt

文献

ab87694 has not yet been referenced specifically in any publications.

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