Recombinant Cardiac Troponin C protein (ab9932)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli

技术指标

Our Abpromise guarantee covers the use of ab9932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 形式Liquid
  • 补充说明Recombinant Human Cardiac troponin-C
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.05% Sodium Azide
    Constituents: 150mM Sodium chloride, 10mM Sodium phosphate, pH 7

常规信息

  • 别名
    • tnnc1a
    • Cardiac troponin C
    • slow skeletal and cardiac muscles
    • TN-C
    • TNC
    • Tnnc1
    • TNNC1_HUMAN
    • TNNI3
    • Troponin C
    • Troponin C slow
    • Troponin C1 slow
    see all
  • 功能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 疾病相关Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt

Recombinant Cardiac Troponin C protein (ab9932)参考文献

ab9932 has not yet been referenced specifically in any publications.

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