概述

  • 产品名称
  • 描述
    兔多克隆抗体to RECK
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 580-629 (HGTSFTIDCN VCSCFAGNLV CSTRLCLSEH SSDDDRRTFT) of Mouse RECK (NP_057887).

  • 阳性对照
    • Mouse spleen lysate.

性能

应用

Our Abpromise guarantee covers the use of ab115844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 106 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
  • 组织特异性
    Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
  • 序列相似性
    Contains 3 Kazal-like domains.
  • 翻译后修饰
    N-glycosylated.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hRECK antibody
    • Membrane anchored glycoprotein (metastasis and invasion) antibody
    • RECK antibody
    • RECK protein antibody
    • RECK_HUMAN antibody
    • Reversion inducing cysteine rich protein with Kazal motifs antibody
    • Reversion-inducing cysteine-rich protein with Kazal motifs antibody
    • ST15 antibody
    • Suppression of tumorigenicity 15 (reversion inducing cysteine rich protein with kazal motifs) antibody
    • Suppressor of tumorigenicity 15 antibody
    • Suppressor of tumorigenicity 15 protein antibody
    see all

图片

  • Anti-RECK antibody (ab115844) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 106 kDa

实验方案

文献

ab115844 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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