功能Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
序列相似性Belongs to the prohibitin family.
发展阶段Levels of expression in fibroblasts decrease heterogeneously during cellular aging.
细胞定位Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear.