The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
功能RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
序列相似性Belongs to the RBM38 family. Contains 1 RRM (RNA recognition motif) domain.
RNA binding region (RNP1, RRM) containing 1 antibody
RNA binding region containing protein 1 antibody
RNA-binding motif protein 38 antibody
RNA-binding protein 38 antibody
RNA-binding region-containing protein 1 antibody
ssDNA binding protein SEB4 antibody
ssDNA-binding protein SEB4 antibody
Anti-RBM38 antibody 图像
Western blot - RBM38 antibody (ab94420)
Anti-RBM38 antibody (ab94420) at 1 µg/ml (in 5% skim milk / PBS buffer ) + HT1080 cell lysate at 10 µg
Secondary HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 25 kDa
Anti-RBM38 antibody (ab94420)参考文献
This product has been referenced in:
Ding C et al. Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. Int J Mol Sci15:4060-76 (2014).
Read more (PubMed: 24663081) »