RabMAb

Anti-Rb2 p130 (phospho S952)抗体[EP2387AY] (ab68136)

概述

  • 产品名称Anti-Rb2 p130 (phospho S952)抗体[EP2387AY]
    参阅全部 Rb2 p130 一抗
  • 描述
    兔单克隆抗体[EP2387AY] to Rb2 p130 (phospho S952)
  • 经测试应用适用于: WB, IHC-P, ICCmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A synthetic phospho-peptide corresponding to residues surrounding serine 952 of human p130

  • 阳性对照
    • Jurkat cell lysate; human breast carcinoma tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab68136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
ICC
  • 应用说明ICC: 1/100 - 1/250.
    IHC-P: 1/100 - 1/250.
    WB: 1/10000 - 1/500000. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).

    Is unsuitable for Flow Cyt or IP.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • 130 kDa retinoblastoma associated protein antibody
      • FLJ26459 antibody
      • p130 antibody
      • PRB 2 antibody
      • PRB2 antibody
      • Rb 2 antibody
      • Rb2 antibody
      • RBL 2 antibody
      • RBL2 antibody
      • RBR 2 antibody
      • RBR2 antibody
      • Retinoblastoma like 2 antibody
      • Retinoblastoma like protein 2 antibody
      • Retinoblastoma related gene antibody
      see all

    Anti-Rb2 p130 (phospho S952) antibody [EP2387AY] 图像

    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab68136 at a dilution of 1/100.
    • All lanes : Anti-Rb2 p130 (phospho S952) antibody [EP2387AY] (ab68136) at 1/500000 dilution

      Lane 1 : Jurkat cell lysate, untreated
      Lane 2 : Jurkat cell lysate, treated with AP

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP-labeled goat anti-mouse at 1/2000 dilution

      Predicted band size : 128 kDa
      Observed band size : 128 kDa

    Anti-Rb2 p130 (phospho S952) antibody [EP2387AY] (ab68136)参考文献

    ab68136 has not yet been referenced specifically in any publications.

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