Anti-Rb2 p130抗体(ab105741)

概述

• 产品名称Anti-Rb2 p130抗体
  参阅全部 Rb2 p130 一抗
• 描述
  兔多克隆抗体to Rb2 p130
• 特异性ab105741 reacts with the Spa3120 domain of pRb2 p130 from Human tissues.
• 经测试应用适用于: WB, ELISAmore details
• 种属反应性
  与反应: Human
  预测可用于: Horse, Cow, Dog, Chimpanzee, Opossum, Orangutan
• 免疫原

  Synthetic peptide with a Cysteine residue linker, corresponding to the Spa310 sequence of Rb2 p130.

• 阳性对照
  • LNCaP whole cell extracts.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride
• Concentration information loading...
• 纯度Protein A purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Cell Biology
  • Cell Cycle
  • Cell Cycle Inhibitors
  • Rb

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cell Cycle Inhibitors
  • Rb

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Rb family

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • LNCaP nuclear extract lysate (ab14857)

应用

靶标

• 相关性Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
• 细胞定位Nuclear
• 数据库链接
  • Entrez Gene: 467978 Chimpanzee
  • Entrez Gene: 533294 Cow
  • Entrez Gene: 478127 Dog
  • Entrez Gene: 5934 Human
  • Omim: 180203 Human
  • SwissProt: Q08999 Human
  • Unigene: 283604 Human
• 别名
  • 130 kDa retinoblastoma associated protein antibody
  • FLJ26459 antibody
  • p130 antibody

  • PRB 2 antibody
  • PRB2 antibody
  • Rb 2 antibody
  • Rb2 antibody
  • RBL 2 antibody
  • RBL2 antibody
  • RBR 2 antibody
  • RBR2 antibody
  • Retinoblastoma like 2 antibody
  • Retinoblastoma like protein 2 antibody
  • Retinoblastoma related gene antibody

  see all