概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionO35433
    • 种属Rat
    • 序列M(1)EQRASLDSEESESPPQENS C(21)
    • 氨基酸1 to 21

技术指标

Our Abpromise guarantee covers the use of ab5858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous VR1 catalog ab3486. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Capsaicin receptor
    • DKFZp434K0220
    • osm 9 like TRP channel 1
    • Osm-9-like TRP channel 1
    • OTRPC1
    • Transient receptor potential cation channel subfamily V member 1
    • TRPV 1
    • Trpv1
    • TRPV1_HUMAN
    • Vanilloid receptor 1
    • Vanilloid receptor subtype 1
    • VR 1
    • VR1
    see all
  • 功能Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
  • 组织特异性Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
  • 序列相似性Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
    Contains 6 ANK repeats.
  • 结构域The association domain (AD) is necessary for self-association.
  • 翻译后修饰Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell projection > dendritic spine membrane.
  • Information by UniProt

Rat VR1 peptide (ab5858)参考文献

ab5858 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab5858.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"