大鼠SynGAP (phospho S1123)肽(ab16982)

概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab16982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • DKFZp761G1421
    • KIAA1938
    • MRD5
    • Neuronal RasGAP
    • OTTHUMP00000064825
    • p135 SynGAP
    • Ras GTPase activating protein SynGAP
    • Ras GTPase-activating protein SynGAP
    • RASA 1
    • RASA 5
    • RASA1
    • RASA5
    • SYGP1_HUMAN
    • Synaptic Ras GAP 1
    • Synaptic Ras GTPase activating protein
    • Synaptic Ras GTPase activating protein 1
    • Synaptic Ras GTPase activating protein 1 homolog
    • Synaptic Ras GTPase activating protein 135kDa
    • Synaptic Ras GTPase-activating protein 1
    • Synaptic Ras-GAP 1
    • SYNGAP 1
    • SYNGAP1
    see all
  • 功能Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
  • 疾病相关Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
  • 序列相似性Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
  • 翻译后修饰Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.
  • Information by UniProt

Rat SynGAP (phospho S1123) peptide (ab16982)参考文献

ab16982 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab16982.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"