概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Rat
    • 序列SQENPNTYSEDLDV
    • 氨基酸235 to 248

技术指标

Our Abpromise guarantee covers the use of ab38201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 100% dH2O

常规信息

  • 别名
    • ADCA
    • Alpha neoendorphin
    • Beta neoendorphin
    • Beta-neoendorphin-dynorphin
    • Big Dyn
    • Big dynorphin
    • Dyn
    • Dyn-A17
    • Dyn-B
    • Dynorphin A
    • Dynorphin A(1-13)
    • Dynorphin A(1-17)
    • Dynorphin A(1-8)
    • Dynorphin B
    • Dynorphin B(1-13)
    • Dynorphin B-29
    • Enkephalin B
    • Leu enkephalin
    • Leumorphin
    • Neoendorphin dynorphin enkephalin prepropeptide
    • PDYN
    • PDYN_HUMAN
    • PENKB
    • Preprodynorphin
    • Preproenkephalin B
    • Prodynorphin
    • Proenkephalin B
    • Rimorphin
    • SCA23
    see all
  • 功能Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • 疾病相关Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • 序列相似性Belongs to the opioid neuropeptide precursor family.
  • 翻译后修饰The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 细胞定位Secreted.
  • Information by UniProt

Rat ProDynorphin peptide (ab38201)参考文献

ab38201 has not yet been referenced specifically in any publications.

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