特异性ab99569 reacts with mouse IgD of all haplotypes (e.g., IgDa, IgDb, IgDc), and does not react with other immunoglobulin isotypes. ab99569 does not induce proliferation of mature B cells in vitro, nor does in vivo injection of the monoclonal antibody have any effect on activation of mature B lymphocytes.
Nitschke L et al. Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. Proc Natl Acad Sci U S A90:1887-91 (1993).
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