概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab47101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CGRP antibody (ab47027)

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Calcitonin/calcitonin related polypeptide alpha
    • Alpha type CGRP
    • Beta type CGRP
    • CALC1
    • CALC2
    • CALCA
    • CALCB
    • Calcitonin 1
    • Calcitonin 2
    • Calcitonin gene related peptide I
    • Calcitonin gene related peptide II
    • Calcitonin related polypeptide alpha
    • Calcitonin related polypeptide beta
    • CGRP
    • CGRP I
    • CGRP II
    • CGRP1
    • CGRP2
    • CT
    • Katacalcin
    • KC
    see all
  • 相关性CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
  • 细胞定位Endoplasmic reticulum and Secreted

Rat CGRP peptide (ab47101)参考文献

This product has been referenced in:
  • Harrington AM  et al. Sprouting of colonic afferent central terminals and increased spinal MAP kinase expression in a mouse model of chronic visceral hypersensitivity. J Comp Neurol : (2012). Read more (PubMed: 22237807) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"