大鼠Calcium Sensing Receptor肽(ab41761)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Rat
    • 序列ALAWHSSAYGPDQRAQ
    • 氨基酸12 to 27

技术指标

Our Abpromise guarantee covers the use of ab41761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Neutralising

    Blocking

  • 纯度> 95 % SDS-PAGE.
    >95% pure.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • Ca sensing receptor
    • Ca2+ sensing receptor
    • Ca2+ sensing receptor 1
    • CAR
    • CaSR
    • CASR_HUMAN
    • EIG8
    • Extracellular calcium sensing receptor
    • Extracellular calcium sensing receptor [Precursor]
    • Extracellular calcium-sensing receptor
    • FHH
    • FIH
    • GPRC2A
    • HHC
    • HHC1
    • Hypocalciuric hypercalcemia 1
    • Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism
    • MGC138441
    • NSHPT
    • Parathyroid Ca(2+) sensing receptor 1
    • Parathyroid Cell calcium sensing receptor
    • Parathyroid Cell calcium-sensing receptor
    • PCAR 1
    • PCaR1
    see all
  • 功能Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
  • 组织特异性Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
  • 疾病相关Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels.
    Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]. NSHPT is a rare autosomal recessive life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH.
    Defects in CASR are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. An autosomal recessive form of FIH also exists.
    Defects in CASR are the cause of idiopathic generalized epilepsy type 8 (IGE8) [MIM:612899]; also known as EIG8. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable, but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized tonic-clonic seizures.
    Note=Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations.
  • 序列相似性Belongs to the G-protein coupled receptor 3 family.
  • 翻译后修饰N-glycosylated.
    Ubiquitinated by RNF19A; which induces proteasomal degradation.
  • 细胞定位Cell membrane.
  • Information by UniProt

Rat Calcium Sensing Receptor peptide (ab41761)参考文献

ab41761 has not yet been referenced specifically in any publications.

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