The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions. - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer. - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent. - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised. - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
5 Hydroxytryptamine 2C receptor
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
5-hydroxytryptamine receptor 1C
5-hydroxytryptamine receptor 2C
5Hydroxytryptamine 2C receptor
serotonin 1c receptor
serotonin 2c receptor
Serotonin 5-HT-2C receptor
Serotonin receptor 2C
功能This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
序列相似性Belongs to the G-protein coupled receptor 1 family.
结构域The PDZ domain-binding motif is involved in the interaction with MPDZ.
Yu HJ & Yamaguchi A Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Neurophysiol103:648-58 (2010).
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